ZFIN ID: ZDB-GENE-040426-1702
Gene Name: exosome component 4
Gene Symbol: exosc4    Nomenclature History

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Previous Names: exosome complex exonuclease RRP41 (1), zgc:73175

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have exonuclease activity. Predicted to be involved in RNA metabolic process. Predicted to localize to cytoplasmic exosome (RNase complex); nuclear exosome (RNase complex); and nucleolus. Is expressed in several structures, including alar plate midbrain region; immature eye; midbrain; pectoral fin bud; and segmental plate. Orthologous to human EXOSC4 (exosome component 4).
Genome Resources: Alliance (1),  Gene:393712 (1),  Ensembl(GRCz11):ENSDARG00000103432 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi340bTg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH exosc4 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH exosc4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process nuclear mRNA surveillance (more)
    Cellular Component cytoplasmic exosome (RNase complex) (more)
    Molecular Function exonuclease activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA exosc4-201 (1)    Ensembl 782
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM exosc4 No data available
    MARKER RELATIONSHIPS
    exosc4 Contained in: [Fosmid] ZFOS-2284C12 (1)
    exosc4 Encodes: [cDNA] MGC:73175 (1), MGC:174480 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200739 (1) 1647 nt
    Genomic GenBank:FO704880 (1) 37227 nt
    Select Tool
    Polypeptide UniProtKB:Q6PBZ8 (1) 245 aa
    Sequence Information (all 17)
    ORTHOLOGY for exosc4 ( Chr: 2 )
    CITATIONS (25)