ZFIN ID: ZDB-GENE-040426-1693
Gene Name: guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b
Gene Symbol: gnao1b    Nomenclature History

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Previous Names: Galpha o2 (1), zgc:73153 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway and dopamine receptor signaling pathway. Predicted to localize to heterotrimeric G-protein complex. Is expressed in nervous system and pronephric duct. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 17. Orthologous to human GNAO1 (G protein subunit alpha o1).
Genome Resources: Alliance (1),  Gene:393801 (1),  Ensembl(GRCz11):ENSDARG00000036058 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20958 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44665 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gnao1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    early infantile epileptic encephalopathy 17 Alliance Epileptic encephalopathy, early infantile, 17 615473
    Neurodevelopmental disorder with involuntary movements 617493
    DISEASE ASSOCIATED WITH gnao1b VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript gnao1b-202 (1)    Ensembl 735
    mRNA gnao1b-201 (1)    Ensembl 2396
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gnao1b No data available
    MARKER RELATIONSHIPS
    gnao1b Contained in: [BAC] DKEY-97O18 (1) (order this)
    gnao1b Encodes: [cDNA] MGC:73153 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200828 (1) 2229 nt
    Genomic GenBank:CR352249 (1) 180142 nt
    Select Tool
    Polypeptide UniProtKB:Q6P967 (1) 354 aa
    Sequence Information (all 10)
    ORTHOLOGY for gnao1b ( Chr: 7 )
    CITATIONS (23)