ZFIN ID: ZDB-GENE-040426-1686
Gene Name: COP9 signalosome subunit 5
Gene Symbol: cops5    Nomenclature History

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Previous Names: jab1 (1), zgc:73130 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have NEDD8-specific protease activity and metallopeptidase activity. Involved in vestibular receptor cell development. Predicted to localize to COP9 signalosome and cytosol. Is expressed in head. Orthologous to human COPS5 (COP9 signalosome subunit 5).
Genome Resources: Alliance (1),  Gene:393698 (1),  Ensembl(GRCz11):ENSDARG00000057624 (2)
GENE EXPRESSION
All Expression Data: Fig. 1 from Weber et al., 2017
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa8923 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39450 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44139 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cops5 N/A 1
    MO2-cops5 N/A 1
    PHENOTYPE
    Data: 2 figures from Weber et al., 2017
    Observed in:
    DISEASE ASSOCIATED WITH cops5 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cops5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process vestibular receptor cell development (more)
    Cellular Component cytosol (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cops5-201 (1)    Ensembl 1387
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cops5 No data available
    MARKER RELATIONSHIPS
    cops5 Contained in: [BAC] CH211-153D8 (1)
    cops5 Encodes: [EST] IMAGE:7142720 (1)
    [cDNA] MGC:73130 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200725 (1) 1358 nt
    Genomic GenBank:BX640462 (1) 173882 nt
    Select Tool
    Polypeptide UniProtKB:Q6PC30 (1) 334 aa
    Sequence Information (all 10)
    ORTHOLOGY for cops5 ( Chr: 24 )
    CITATIONS (29)