Gene

polr1b

ID
ZDB-GENE-040426-1598
Name
RNA polymerase I subunit B
Symbol
polr1b Nomenclature History
Previous Names
  • wu:fc91a05
  • zgc:66298 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Exhibits RNA polymerase I activity. Is predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Involved in neural crest cell migration. Predicted to localize to RNA polymerase I complex. Is expressed in several structures, including alar plate midbrain region; eye; liver; musculature system; and optic tectum. Used to study Treacher Collins syndrome. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 4. Orthologous to human POLR1B (RNA polymerase I subunit B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Sanchez et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With polr1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Treacher Collins syndrome 4 Alliance Treacher-Collins syndrome 4 618939
Associated With polr1b Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR007121 RNA polymerase, beta subunit, conserved site
Domain IPR007120 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain
Domain IPR007641 RNA polymerase Rpb2, domain 7
Domain IPR007642 RNA polymerase Rpb2, domain 2
Domain IPR007644 RNA polymerase, beta subunit, protrusion
Domain IPR007645 RNA polymerase Rpb2, domain 3
Domain IPR009674 DNA-directed RNA polymerase I subunit RPA2, domain 4
Family IPR015712 DNA-directed RNA polymerase, subunit 2
Homologous_superfamily IPR014724 RNA polymerase Rpb2, OB-fold
Homologous_superfamily IPR037033 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily
Homologous_superfamily IPR037034 RNA polymerase Rpb2, domain 2 superfamily
Domain Details Per Protein
Protein Length DNA-directed RNA polymerase I subunit RPA2, domain 4 DNA-directed RNA polymerase, subunit 2 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily RNA polymerase, beta subunit, conserved site RNA polymerase, beta subunit, protrusion RNA polymerase Rpb2, domain 2 RNA polymerase Rpb2, domain 2 superfamily RNA polymerase Rpb2, domain 3 RNA polymerase Rpb2, domain 7 RNA polymerase Rpb2, OB-fold
UniProtKB:Q7SXI3 150
UniProtKB:B8JKD7 1132
UniProtKB:Q4V967 1132
UniProtKB:A2VCY0 1132
UniProtKB:A0A0R4IKW5 146
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations