Gene

pank4

ID

ZDB-GENE-040426-1592

Name

pantothenate kinase 4 (inactive)

Symbol

pank4 Nomenclature History

Previous Names

zgc:66285 (1)

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable pantothenate kinase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in cataract. Orthologous to human PANK4 (pantothenate kinase 4 (inactive)).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pank4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Cataract 49	619593

Associated With pank4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002791	Damage-control phosphatase ARMT1-like, metal-binding domain
Family	IPR004567	Type II pantothenate kinase
Family	IPR015844	Pantothenate kinase, acetyl-CoA regulated, two-domain type
Homologous_superfamily	IPR035073	At2g17340, three-helix bundle domain
Homologous_superfamily	IPR036075	Damage-control phosphatase ARMT1-like, metal-binding domain superfamily
Homologous_superfamily	IPR043129	ATPase, nucleotide binding domain

Domain Details Per Protein

Protein	Length	At2g17340, three-helix bundle domain	ATPase, nucleotide binding domain	Damage-control phosphatase ARMT1-like, metal-binding domain	Damage-control phosphatase ARMT1-like, metal-binding domain superfamily	Pantothenate kinase, acetyl-CoA regulated, two-domain type	Type II pantothenate kinase
UniProtKB:A0A8M3BDL0 InterPro	776
UniProtKB:A0A8M3B6T9 InterPro	748
UniProtKB:A0A8M2B2I2 InterPro	778
UniProtKB:A0A8M1P4R1 InterPro	780
UniProtKB:A0A8M3AXH7 InterPro	752
UniProtKB:A0A8M2B1X9 InterPro	774

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	pank4-202 (1) Ensembl	Ensembl	807 nt	Select Tool ZFIN BLAST
mRNA	pank4-201 (1) Ensembl	Ensembl	1,884 nt	Select Tool ZFIN BLAST
mRNA	pank4-203 (1) Ensembl	Ensembl	892 nt	Select Tool ZFIN BLAST
mRNA	pank4-204 (1) Ensembl	Ensembl	872 nt	Select Tool ZFIN BLAST
mRNA	pank4-205 (1) Ensembl	Ensembl	572 nt	Select Tool ZFIN BLAST
mRNA	pank4-206 (1) Ensembl	Ensembl	1,667 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations