ZFIN ID: ZDB-GENE-040426-1582
Gene Name: 3-hydroxyisobutyrate dehydrogenase b
Gene Symbol: hibadhb    Nomenclature History

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Previous Names: hibadh, zgc:66262

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have 3-hydroxyisobutyrate dehydrogenase activity. Predicted to be involved in valine catabolic process. Predicted to localize to the mitochondrion. Is expressed in mesenchyme pectoral fin and myoblast. Orthologous to human HIBADH (3-hydroxyisobutyrate dehydrogenase).
Genome Resources: Alliance (1),  Gene:394135 (1),  Ensembl(GRCz11):ENSDARG00000007959 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:66262]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la012869Tg Transgenic Insertion Unknown Unknown DNA
sa2861 Point Mutation Unknown Premature Stop ENU
sa5622 Point Mutation Unknown Premature Stop ENU
PHENOTYPE No data available
DISEASE ASSOCIATED WITH hibadhb HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH hibadhb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process branched-chain amino acid catabolic process (more)
Molecular Function 3-hydroxyisobutyrate dehydrogenase activity (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Conserved_site IPR002204 3-hydroxyisobutyrate dehydrogenase-related, conserved site
Domain IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
Homologous_superfamily IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
Family IPR011548 3-hydroxyisobutyrate dehydrogenase
Homologous_superfamily IPR013328 6-phosphogluconate dehydrogenase, domain 2
Family IPR015815 3-hydroxyisobutyrate dehydrogenase-related
Domain IPR029154 3-hydroxyisobutyrate dehydrogenase, NAD-binding domain
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA hibadhb-201 (1)    Ensembl 1584
ncRNA hibadhb-002 (1)    Ensembl 766
hibadhb-003 (1)    Ensembl 642
hibadhb-004 (1)    Ensembl 947
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM hibadhb No data available
MARKER RELATIONSHIPS
hibadhb Contained in: [BAC] DKEY-45E15 (1) (order this)
hibadhb Encodes: [cDNA] MGC:66262 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_201160 (1) 1402 bp
Genomic GenBank:CR392024 (1) 183486 bp
Select Tool
Polypeptide UniProtKB:F1QE62 (1) 329 aa
Sequence Information (all 9)
ORTHOLOGY for hibadhb ( Chr: 16 )
CITATIONS (27)