ZFIN ID: ZDB-GENE-040426-1571
Gene Name: cytochrome P450, family 2, subfamily K, polypeptide 6
Gene Symbol: cyp2k6    Nomenclature History

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Previous Name: zgc:66225 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Involved in aflatoxin B1 metabolic process. Predicted to localize to the cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver and ovary. Orthologous to human CYP2W1 (cytochrome P450 family 2 subfamily W member 1).
Genome Resources: Alliance (1),  Gene:393481 (1), 
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:66225]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa19953 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cyp2k6 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cyp2k6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process aflatoxin metabolic process (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function heme binding (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR001128 Cytochrome P450
    Family IPR002401 Cytochrome P450, E-class, group I
    Conserved_site IPR017972 Cytochrome P450, conserved site
    Homologous_superfamily IPR036396 Cytochrome P450 superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cyp2k6-204 (1)    Ensembl 2125
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp2k6 No data available
    MARKER RELATIONSHIPS
    cyp2k6 Contained in: [BAC] CH211-8C17 (1), CH211-155I15 (1)
    cyp2k6 Encodes: [cDNA] MGC:55885 (1), MGC:66225 (1), MGC:192034 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200509 (1) 1898 bp
    Genomic GenBank:AL929078 (1) 171571 bp
    Select Tool
    Polypeptide UniProtKB:E9QBY0 (1) 510 aa
    Sequence Information (all 23)
    ORTHOLOGY for cyp2k6 ( Chr: 3 )
    CITATIONS (37)