ZFIN ID: ZDB-GENE-040426-1565
Gene Name: acyl-CoA synthetase long chain family member 4a
Gene Symbol: acsl4a    Nomenclature History

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Previous Names: acsl4, acsl4b, zgc:66186 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have arachidonate-CoA ligase activity and long-chain fatty acid-CoA ligase activity. Involved in dorsal/ventral pattern formation and regulation of signal transduction. Predicted to localize to endoplasmic reticulum; lipid droplet; and plasma membrane. Is expressed in several structures, including digestive system; heart; nervous system; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4).
Genome Resources: Alliance (1),  Gene:393622 (1),  Ensembl(GRCz11):ENSDARG00000004078 (2)
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 6 figures (9 images) from Thisse et al., 2004 [MGC:66186]
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa35699 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-acsl4a N/A 1
    MO2-acsl4a N/A 1
    MO3-acsl4a N/A 1
    MO4-acsl4a N/A 1
    MO5-acsl4a N/A 1
    DISEASE ASSOCIATED WITH acsl4a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    non-syndromic X-linked intellectual disability Alliance Mental retardation, X-linked 63 300387
    DISEASE ASSOCIATED WITH acsl4a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal/ventral pattern formation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA acsl4a-201 (1)    Ensembl 3852
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM acsl4a No data available
    MARKER RELATIONSHIPS
    acsl4a Contained in: [BAC] CH73-86C12 (1), DKEY-18F5 (1) (order this)
    acsl4a Encodes: [cDNA] MGC:66186 (1), MGC:191744 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200649 (1) 3863 nt
    Genomic GenBank:BX088535 (1) 197465 nt
    Select Tool
    Polypeptide UniProtKB:F1R452 (1) 706 aa
    Sequence Information (all 18)
    ORTHOLOGY for acsl4a ( Chr: 14 )
    CITATIONS (28)