Gene

acsl4a

ID
ZDB-GENE-040426-1565
Name
acyl-CoA synthetase long chain family member 4a
Symbol
acsl4a Nomenclature History
Previous Names
  • acsl4
  • acsl4b
  • zgc:66186 (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have arachidonate-CoA ligase activity. Involved in dorsal/ventral pattern formation and regulation of signal transduction. Predicted to localize to endoplasmic reticulum; lipid droplet; and plasma membrane. Is expressed in several structures, including digestive system; heart; nervous system; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 63. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Miyares et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With acsl4a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
non-syndromic X-linked intellectual disability 63 Alliance Mental retardation, X-linked 63 300387
Associated With acsl4a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020845 AMP-binding, conserved site
Domain IPR000873 AMP-dependent synthetase/ligase
Domain IPR020459 AMP-binding
Homologous_superfamily IPR042099 AMP-dependent synthetase-like superfamily
Domain Details Per Protein
Protein Length AMP-binding AMP-binding, conserved site AMP-dependent synthetase/ligase AMP-dependent synthetase-like superfamily
UniProtKB:Q6PFP1 706
UniProtKB:F1R452 706
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations