Gene

acsl4a

ID
ZDB-GENE-040426-1565
Name
acyl-CoA synthetase long chain family member 4a
Symbol
acsl4a Nomenclature History
Previous Names
  • acsl4
  • acsl4b
  • zgc:66186 (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have arachidonate-CoA ligase activity and long-chain fatty acid-CoA ligase activity. Involved in dorsal/ventral pattern formation and regulation of signal transduction. Predicted to localize to endoplasmic reticulum; lipid droplet; and plasma membrane. Is expressed in several structures, including digestive system; heart; nervous system; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4).
Genome Resources
Note
None
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Miyares et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With acsl4a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
non-syndromic X-linked intellectual disability Alliance Mental retardation, X-linked 63 300387
Associated With acsl4a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020845 AMP-binding, conserved site
Domain IPR000873 AMP-dependent synthetase/ligase
Domain IPR020459 AMP-binding
Homologous_superfamily IPR042099 AMP-dependent synthetase-like superfamily
Domain Details Per Protein
Protein Length AMP-binding AMP-binding, conserved site AMP-dependent synthetase/ligase AMP-dependent synthetase-like superfamily
UniProtKB:Q6PFP1 706
UniProtKB:F1R452 706
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations