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ZIRC
ZFIN ID: ZDB-GENE-040426-1556
Gene Name: dynamin 1-like
Gene Symbol: dnm1l    Nomenclature History

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Previous Name: zgc:66163 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have GTPase activity; microtubule binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including dynamin family protein polymerization involved in mitochondrial fission; intracellular distribution of mitochondria; and mitochondrial fragmentation involved in apoptotic process. Predicted to localize to the cytosol; mitochondrial outer membrane; and peroxisome. Human ortholog(s) of this gene implicated in brain disease and optic atrophy. Is expressed in brain. Orthologous to human DNM1L (dynamin 1 like).
Genome Resources: Alliance (1),  Gene:393896 (1),  Ensembl(GRCz11):ENSDARG00000015006 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:66163]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7139392]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ct111aGt Transgenic Insertion Unknown Unknown DNA
sa24668 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44293 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH dnm1l HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    optic atrophy 5 Alliance Optic atrophy 5 610708
    Encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1 614388
    DISEASE ASSOCIATED WITH dnm1l VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dynamin family protein polymerization involved in mitochondrial fission (more)
    Cellular Component cytosol (more)
    Molecular Function GTPase activity (more)
    GO Terms (all 30)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dnm1l-201 (1)    Ensembl 2481
    dnm1l-202 (1)    Ensembl 280
    dnm1l-203 (1)    Ensembl 683
    dnm1l-204 (1)    Ensembl 2272
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dnm1l No data available
    MARKER RELATIONSHIPS
    dnm1l Contained in: [BAC] DKEY-206M15 (1) (order this)
    dnm1l Encodes: [EST] IMAGE:7139392 (1) (order this)
    [cDNA] MGC:66163 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200922 (1) 2455 bp
    Genomic GenBank:BX928758 (1) 199974 bp
    Select Tool
    Polypeptide UniProtKB:A0A140LH30 (1) 715 aa
    Sequence Clusters UniGene:77967 (1)
    Sequence Information (all 20)
    ORTHOLOGY for dnm1l ( Chr: 25 )
    CITATIONS (34)