ZFIN Gene: nae1

ZFIN ID: ZDB-GENE-040426-1552

ZFIN ID: ZDB-GENE-040426-1552

Gene Name:

nedd8 activating enzyme E1 subunit 1

Gene Symbol:

nae1 Nomenclature History

Previous Names:

appbp1, zgc:66148

Gene Type:

protein_coding_gene

Location:

Chr: 7 Mapping Details/Browsers

Description:

Predicted to have NEDD8 activating enzyme activity. Predicted to be involved in protein neddylation. Predicted to localize to cytoplasm. Orthologous to human NAE1 (NEDD8 activating enzyme E1 subunit 1).

Genome Resources:

Alliance (1), Gene:573336 (1), Ensembl(GRCz11):ENSDARG00000011301 (1)

GENE EXPRESSION
All Expression Data:	3 figures from 2 publications
Directly Submitted Expression Data:	1 figure (1 image) from Thisse et al., 2004 [MGC:66148]
	1 figure (1 image) from Thisse et al., 2004 [IMAGE:7138842]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
	unspecified
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la026093Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa34155	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa40985	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

PHENOTYPE No data available

DISEASE ASSOCIATED WITH nae1 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH nae1 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	protein neddylation (more)
Cellular Component	cytoplasm (more)
Molecular Function	NEDD8 activating enzyme activity (more)

GO Terms (all 5)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	nae1-201 (1)	1829	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM nae1 No data available

MARKER RELATIONSHIPS

nae1 Contained in:	[BAC] DKEY-71E3 (1) (order this)
nae1 Encodes:	[EST] IMAGE:7138842 (1) [cDNA] MGC:66148 (1), MGC:171400 (1), MGC:198186 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_200499 (1)	1843 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX511136	187217 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A0R4ICE9 (1)	548 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 21)

ORTHOLOGY for nae1 ( Chr: 7 )

CITATIONS (26)

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