ZFIN ID: ZDB-GENE-040426-1523
Gene Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Gene Symbol: abcc2    Nomenclature History

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Previous Names: mrp2 (1), zgc:66072 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to localize to apical plasma membrane. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder (multiple); carcinoma (multiple); drug-induced hepatitis; leukemia (multiple); and non-alcoholic fatty liver disease. Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2).
Genome Resources: Alliance (1),  Gene:393561 (1),  Ensembl(GRCz11):ENSDARG00000014031 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Larval:Day 4 (96.0h-120.0h) to Larval:Day 4 (96.0h-120.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2688 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6282 Point Mutation Unknown Premature Stop ENU
    sa11900 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19049 Point Mutation Unknown Premature Stop ENU
    sa22191 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH abcc2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Dubin-Johnson syndrome Alliance Dubin-Johnson syndrome 237500
    DISEASE ASSOCIATED WITH abcc2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process transmembrane transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATPase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA abcc2-201 (1)    Ensembl 4843
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM abcc2 No data available
    MARKER RELATIONSHIPS
    abcc2 Contained in: [BAC] CH211-250O1 (1), DKEY-58O21 (1) (order this)
    abcc2 Encodes: [cDNA] MGC:66072 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200589 (1) 4926 nt
    Genomic GenBank:CR354539 145294 nt
    Select Tool
    Polypeptide UniProtKB:F1DB26 (1) 1567 aa
    Sequence Information (all 17)
    ORTHOLOGY for abcc2 ( Chr: 13 )
    CITATIONS (41)