Gene

abcc2

ID
ZDB-GENE-040426-1523
Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Symbol
abcc2 Nomenclature History
Previous Names
  • mrp2 (1)
  • zgc:66072 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to localize to membrane. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder (multiple); carcinoma (multiple); drug-induced hepatitis; leukemia (multiple); and non-alcoholic fatty liver disease. Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With abcc2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Dubin-Johnson syndrome Alliance Dubin-Johnson syndrome 237500
Associated With abcc2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017871 ABC transporter, conserved site
Domain IPR003439 ABC transporter-like
Domain IPR003593 AAA+ ATPase domain
Domain IPR011527 ABC transporter type 1, transmembrane domain
Family IPR005292 Multi drug resistance-associated protein
Family IPR030247 Canalicular multispecific organic anion transporter 1
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036640 ABC transporter type 1, transmembrane domain superfamily
Domain Details Per Protein
Protein Length AAA+ ATPase domain ABC transporter, conserved site ABC transporter-like ABC transporter type 1, transmembrane domain ABC transporter type 1, transmembrane domain superfamily Canalicular multispecific organic anion transporter 1 Multi drug resistance-associated protein P-loop containing nucleoside triphosphate hydrolase
UniProtKB:F1DB26 1567
UniProtKB:F1RCV0 1553
UniProtKB:A9JSW5 313
UniProtKB:Q6PH26 1567
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations