header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-040426-1510
Gene Name: mitochondrial fission factor
Gene Symbol: mff    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: zgc:66022

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have protein homodimerization activity. Predicted to be involved in mitochondrial fission; positive regulation of mitochondrial fission; and positive regulation of protein targeting to membrane. Predicted to localize to the peroxisome. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human MFF (mitochondrial fission factor).
Genome Resources: Alliance (1),  Gene:393508 (1),  Ensembl(GRCz11):ENSDARG00000053753 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:66022]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa17105 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32055 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mff HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Encephalopathy due to defective mitochondrial and peroxisomal fission 2 617086
    DISEASE ASSOCIATED WITH mff VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process mitochondrial fission (more)
    Cellular Component peroxisome (more)
    Molecular Function protein homodimerization activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR008518 (1)
  • InterPro:IPR039433 (1)
  • Pfam:PF05644 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mff-201 (1)    Ensembl 1571
    mff-202 (1)    Ensembl 516
    mff-203 (1)    Ensembl 1059
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mff No data available
    MARKER RELATIONSHIPS
    mff Contained in: [BAC] CH211-158N6 (1) (order this)
    mff Encodes: [cDNA] MGC:66022 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200536 (1) 1562 bp
    Genomic GenBank:CR354553 (1) 143156 bp
    Select Tool
    Polypeptide UniProtKB:F1Q877 (1) 344 aa
    Sequence Clusters UniGene:81921 (1)
    Sequence Information (all 18)
    ORTHOLOGY for mff ( Chr: 15 )
    CITATIONS (18)