ZFIN ID: ZDB-GENE-040426-1505
Gene Name: methylthioadenosine phosphorylase
Gene Symbol: mtap    Nomenclature History

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Previous Name: zgc:66012

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have S-methyl-5-thioadenosine phosphorylase activity. Predicted to be involved in L-methionine salvage from methylthioadenosine. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in biliary tract benign neoplasm and diaphyseal medullary stenosis with malignant fibrous histiocytoma. Orthologous to human MTAP (methylthioadenosine phosphorylase).
Genome Resources: Alliance (1),  Gene:393526 (1),  Ensembl(GRCz11):ENSDARG00000037261 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:66012]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa39619 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mtap HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    diaphyseal medullary stenosis with malignant fibrous histiocytoma Alliance Diaphyseal medullary stenosis with malignant fibrous histiocytoma 112250
    DISEASE ASSOCIATED WITH mtap VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process L-methionine salvage from methylthioadenosine (more)
    Cellular Component cytoplasm (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mtap-201 (1)    Ensembl 1283
    ncRNA mtap-002 (1) 185
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mtap No data available
    MARKER RELATIONSHIPS
    mtap Contained in: [BAC] CH211-145B13 (1), DKEY-123O10 (1) (order this)
    mtap Encodes: [cDNA] MGC:56267 (1), MGC:66012 (1), MGC:191975 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200554 (1) 1255 nt
    Genomic GenBank:CT573245 (1) 196368 nt
    Select Tool
    Polypeptide UniProtKB:B2GQM6 (1) 280 aa
    Sequence Information (all 18)
    ORTHOLOGY for mtap ( Chr: 1 )
    CITATIONS (29)