Gene

polr1c

ID
ZDB-GENE-040426-1495
Name
RNA polymerase I and III subunit C
Symbol
polr1c Nomenclature History
Previous Names
  • zgc:65973
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Is predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Involved in cartilage development; embryonic viscerocranium morphogenesis; and ribosome biogenesis. Predicted to localize to RNA polymerase I complex and RNA polymerase III complex. Is expressed in several structures, including head; immature eye; midbrain; midbrain hindbrain boundary; and segmental plate. Used to study Treacher Collins syndrome. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 3 and hypomyelinating leukodystrophy 11. Orthologous to human POLR1C (RNA polymerase I and III subunit C).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
22 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With polr1c Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypomyelinating leukodystrophy 11 Alliance Leukodystrophy, hypomyelinating, 11 616494
Treacher Collins syndrome 3 Alliance Treacher Collins syndrome 3 248390
Associated With polr1c Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001514 DNA-directed RNA polymerase, 30-40kDa subunit, conserved site
Domain IPR011262 DNA-directed RNA polymerase, insert domain
Domain IPR011263 DNA-directed RNA polymerase, RpoA/D/Rpb3-type
Family IPR033901 DNA-directed RNA polymerases I and III subunit AC40
Homologous_superfamily IPR036603 RNA polymerase, RBP11-like subunit
Homologous_superfamily IPR036643 DNA-directed RNA polymerase, insert domain superfamily
Domain Details Per Protein
Protein Length DNA-directed RNA polymerase, 30-40kDa subunit, conserved site DNA-directed RNA polymerase, insert domain DNA-directed RNA polymerase, insert domain superfamily DNA-directed RNA polymerase, RpoA/D/Rpb3-type DNA-directed RNA polymerases I and III subunit AC40 RNA polymerase, RBP11-like subunit
UniProtKB:A2ATX1 362
UniProtKB:A2ATX2 197
UniProtKB:Q6PHE7 347
UniProtKB:Q6DRM8 343
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations