ZFIN ID: ZDB-GENE-040426-1432
Gene Name: programmed cell death 10a
Gene Symbol: pdcd10a    Nomenclature History

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Previous Names: ccm3a (1), pdcd10, zgc:65826

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Involved in blood vessel morphogenesis; chordate embryonic development; and heart morphogenesis. Predicted to localize to Golgi membrane and plasma membrane. Is expressed in several structures, including blastomere; brain; inner ear; intestine; and somite. Human ortholog(s) of this gene implicated in cerebral cavernous malformation 3. Orthologous to human PDCD10 (programmed cell death 10).
Genome Resources: Alliance (1),  Gene:393527 (1),  Ensembl(GRCz11):ENSDARG00000035054 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:65826]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020463Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pdcd10a,pdcd10b N/A 2
    MO2-pdcd10a N/A 1
    MO3-pdcd10a N/A 1
    MO4-pdcd10a,pdcd10b N/A 1
    MO5-pdcd10a N/A 1
    MO6-pdcd10a N/A 1
    MO7-pdcd10a N/A 1
    MO8-pdcd10a N/A 1
    PHENOTYPE
    Data: text only from Voss et al., 2009
    Observed in:
    DISEASE ASSOCIATED WITH pdcd10a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    cerebral cavernous malformation 3 Alliance Cerebral cavernous malformations 3 603285
    DISEASE ASSOCIATED WITH pdcd10a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood vessel development (more)
    Cellular Component cytoplasm (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pdcd10a No data available
    MARKER RELATIONSHIPS
    pdcd10a Contained in: [BAC] CH211-167C22 (1)
    pdcd10a Encodes: [cDNA] MGC:65826 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200555 (1) 1268 nt
    Genomic GenBank:AL845366 149189 nt
    Select Tool
    Polypeptide UniProtKB:Q6PHH3 (1) 210 aa
    Sequence Information (all 16)
    ORTHOLOGY for pdcd10a ( Chr: 18 )
    CITATIONS (27)