ZFIN ID: ZDB-GENE-040426-1401
Gene Name: calcium channel, voltage-dependent, gamma subunit 2a
Gene Symbol: cacng2a    Nomenclature History

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Previous Names: cacng2, zgc:64200 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have voltage-gated calcium channel activity. Involved in AMPA selective glutamate receptor signaling pathway. Predicted to localize to AMPA glutamate receptor complex and postsynaptic density membrane. Is expressed in brain and central nervous system. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 10. Orthologous to human CACNG2 (calcium voltage-gated channel auxiliary subunit gamma 2).
Genome Resources: Alliance (1),  Gene:393614 (1),  Ensembl(GRCz11):ENSDARG00000032565 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 3 publications
Directly Submitted Expression Data: 4 figures (5 images) from Thisse et al., 2004 [MGC:64200]
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028892Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33187 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40079 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cacng2a N/A 1
    DISEASE ASSOCIATED WITH cacng2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant non-syndromic intellectual disability 10 Alliance ?Mental retardation, autosomal dominant 10 614256
    DISEASE ASSOCIATED WITH cacng2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process AMPA selective glutamate receptor signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium channel activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cacng2a-201 (1)    Ensembl 2994
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cacng2a No data available
    MARKER RELATIONSHIPS
    cacng2a Contained in: [BAC] DKEY-151M15 (1) (order this)
    cacng2a Encodes: [cDNA] MGC:64200 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200641 (1) 3067 nt
    Genomic GenBank:BX901883 (1) 241961 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q6PFS3 (1) 324 aa
    Sequence Information (all 8)
    ORTHOLOGY for cacng2a ( Chr: 3 )
    CITATIONS (25)