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ZIRC
ZFIN ID: ZDB-GENE-040426-1388
Gene Name: gamma-glutamyltransferase 1a
Gene Symbol: ggt1a    Nomenclature History

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Previous Names: ggt1, zgc:64172 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have glutathione hydrolase activity and peptidyltransferase activity. Predicted to be involved in several processes, including peptide metabolic process; response to estradiol; and response to lipopolysaccharide. Predicted to localize to the plasma membrane. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Is expressed in lens and solid lens vesicle. Orthologous to human GGT1 (gamma-glutamyltransferase 1).
Genome Resources: Alliance (1),  Gene:393387 (1),  Ensembl(GRCz11):ENSDARG00000023526 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 4 figures (6 images) from Thisse et al., 2004 [MGC:64172]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Hatching:Long-pec (48.0h-60.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ggt1a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
gamma-glutamyl transpeptidase deficiency Alliance ?Glutathioninuria 231950
DISEASE ASSOCIATED WITH ggt1a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process glutathione catabolic process (more)
Cellular Component integral component of membrane (more)
Molecular Function glutathione hydrolase activity (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000101 (1)
  • InterPro:IPR029055 (1)
  • PROSITE:PS00462 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ggt1a-202 (1)    Ensembl 2192
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ggt1a No data available
    MARKER RELATIONSHIPS
    ggt1a Contained in: [BAC] CH211-286E11 (1) (order this)
    ggt1a Encodes: [cDNA] MGC:64172 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200415 (1) 2296 bp
    Genomic GenBank:CR388077 (1) 192705 bp
    Select Tool
    Polypeptide UniProtKB:B0UXV5 (1) 579 aa
    Sequence Clusters UniGene:26600 (1)
    Sequence Information (all 12)
    ORTHOLOGY for ggt1a ( Chr: 8 )
    CITATIONS (19)