ZFIN ID: ZDB-GENE-040426-1381
Gene Name: CDGSH iron sulfur domain 2
Gene Symbol: cisd2    Nomenclature History

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Previous Name: zgc:64148

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have 2 iron, 2 sulfur cluster binding activity and protein homodimerization activity. Predicted to be involved in autophagy of mitochondrion; multicellular organism aging; and regulation of autophagy. Predicted to localize to endoplasmic reticulum membrane and mitochondrial outer membrane. Human ortholog(s) of this gene implicated in Wolfram syndrome 2. Orthologous to human CISD2 (CDGSH iron sulfur domain 2).
Genome Resources: Alliance (1),  Gene:393354 (1),  Ensembl(GRCz11):ENSDARG00000052703 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:64148]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013675Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1385 Point Mutation Unknown Premature Stop ENU
    zko799b Insertion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cisd2 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cisd2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Wolfram syndrome 2 Alliance Wolfram syndrome 2 604928
    DISEASE ASSOCIATED WITH cisd2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process autophagy of mitochondrion (more)
    Cellular Component endoplasmic reticulum membrane (more)
    Molecular Function 2 iron, 2 sulfur cluster binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cisd2-201 (1)    Ensembl 1312
    cisd2-202 (1)    Ensembl 679
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cisd2 No data available
    MARKER RELATIONSHIPS
    cisd2 Contained in: [BAC] DKEY-162B23 (1) (order this)
    cisd2 Encodes: [cDNA] MGC:64148 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200383 (1) 1320 nt
    Genomic GenBank:CR388005 (1) 197480 nt
    Select Tool
    Polypeptide UniProtKB:Q7T326 (1) 135 aa
    Sequence Information (all 12)
    ORTHOLOGY for cisd2 ( Chr: 1 )
    CITATIONS (27)