Gene

cybb

ID
ZDB-GENE-040426-1380
Name
cytochrome b-245, beta polypeptide (chronic granulomatous disease)
Symbol
cybb Nomenclature History
Previous Names
  • gp91 (1)
  • nox2 (1)
  • zgc:64144 (1)
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have superoxide-generating NAD(P)H oxidase activity. Predicted to be involved in defense response; oxidation-reduction process; and superoxide anion generation. Predicted to localize to NADPH oxidase complex. Is expressed in blood; nervous system; and neutrophil. Human ortholog(s) of this gene implicated in X-linked chronic granulomatous disease; chronic granulomatous disease; and immunodeficiency 34. Orthologous to human CYBB (cytochrome b-245 beta chain).
Genome Resources
Note
None
Expression
All Expression Data
10 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cybb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 34 Alliance Immunodeficiency 34, mycobacteriosis, X-linked 300645
X-linked chronic granulomatous disease Alliance Chronic granulomatous disease, X-linked 306400
Associated With cybb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013112 FAD-binding 8
Domain IPR013121 Ferric reductase, NAD binding domain
Domain IPR013130 Ferric reductase transmembrane component-like domain
Domain IPR017927 FAD-binding domain, ferredoxin reductase-type
Family IPR000778 Cytochrome b245, heavy chain
Homologous_superfamily IPR017938 Riboflavin synthase-like beta-barrel
Homologous_superfamily IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Domain Details Per Protein
Protein Length Cytochrome b245, heavy chain FAD-binding 8 FAD-binding domain, ferredoxin reductase-type Ferredoxin-NADP reductase (FNR), nucleotide-binding domain Ferric reductase, NAD binding domain Ferric reductase transmembrane component-like domain Riboflavin synthase-like beta-barrel
UniProtKB:A0A286Y943 571
UniProtKB:F1QV52 565
UniProtKB:Q7T2A7 565
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations