Gene

fermt3b

ID
ZDB-GENE-040426-1366
Name
FERM domain containing kindlin 3b
Symbol
fermt3b Nomenclature History
Previous Names
  • kindlin-3 (1)
  • zgc:64101
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Is predicted to enable integrin binding activity. Involved in several processes, including integrin activation; platelet aggregation; and regulation of cell-cell adhesion mediated by integrin. Acts upstream of or within cell adhesion and integrin-mediated signaling pathway. Human ortholog(s) of this gene implicated in leukocyte adhesion deficiency 1 and leukocyte adhesion deficiency 3. Orthologous to human FERMT3 (FERM domain containing kindlin 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Pluskota et al., 2011
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fermt3b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
leukocyte adhesion deficiency 3 Alliance Leukocyte adhesion deficiency, type III 612840
Associated With fermt3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001849 Pleckstrin homology domain
Domain IPR019748 FERM central domain
Domain IPR019749 Band 4.1 domain
Domain IPR037837 Kindlin/fermitin, PH domain
Domain IPR040790 Kindlin-2, N-terminal
Family IPR037843 Kindlin/fermitin
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR035963 FERM superfamily, second domain
Domain Details Per Protein
Protein Length Band 4.1 domain FERM central domain FERM superfamily, second domain Kindlin-2, N-terminal Kindlin/fermitin Kindlin/fermitin, PH domain PH-like domain superfamily Pleckstrin homology domain
UniProtKB:F1QPN5 642
UniProtKB:Q6P297 642
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations