ZFIN is now using GRCz12tu for Genomic Data
Gene
lipca
- ID
- ZDB-GENE-040426-1361
- Name
- lipase, hepatic a
- Symbol
- lipca Nomenclature History
- Previous Names
-
- lipc
- zgc:64081
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable apolipoprotein binding activity; lipoprotein lipase activity; and phospholipase A1 activity. Acts upstream of or within response to hormone. Predicted to be located in extracellular region. Predicted to be part of high-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several structures, including heart; integument; lens; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; familial combined hyperlipidemia; glucose metabolism disease (multiple); obesity; and peripheral vascular disease. Orthologous to human LIPC (lipase C, hepatic type).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64081 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Diabetes mellitus, noninsulin-dependent} | 125853 |
| Hepatic lipase deficiency | 614025 | ||
| [High density lipoprotein cholesterol level QTL 12] | 612797 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001024 | PLAT/LH2 domain |
| Domain | IPR013818 | Lipase |
| Domain | IPR033906 | Lipase, N-terminal |
| Family | IPR000734 | Triacylglycerol lipase family |
| Family | IPR002333 | Hepatic lipase |
| Family | IPR016272 | Lipase, LIPH-type |
| Homologous_superfamily | IPR029058 | Alpha/Beta hydrolase fold |
| Homologous_superfamily | IPR036392 | PLAT/LH2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha/Beta hydrolase fold | Hepatic lipase | Lipase | Lipase, LIPH-type | Lipase, N-terminal | PLAT/LH2 domain | PLAT/LH2 domain superfamily | Triacylglycerol lipase family |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T359 | InterPro | 514 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers