ZFIN ID: ZDB-GENE-040426-1361
Gene Name: lipase, hepatic a
Gene Symbol: lipca    Nomenclature History

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Previous Names: lipc, zgc:64081

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have apolipoprotein binding activity and lipase activity. Involved in response to hormone. Predicted to localize to extracellular space. Is expressed in several structures, including heart; integument; lens; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; coronary artery disease; familial combined hyperlipidemia; peripheral vascular disease; and type 2 diabetes mellitus. Orthologous to human LIPC (lipase C, hepatic type).
Genome Resources: Alliance (1),  Gene:393997 (1),  Ensembl(GRCz11):ENSDARG00000053476 (2)
GENE EXPRESSION
All Expression Data: 11 figures from 7 publications
Directly Submitted Expression Data: 2 figures (2 images) from Thisse et al., 2004 [MGC:64081]
Wild-type Stages, Structures: Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la016069Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa189 Point Mutation Unknown Unknown ENU
    sa12401 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20975 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH lipca HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    type 2 diabetes mellitus Alliance {Diabetes mellitus, noninsulin-dependent} 125853
    Hepatic lipase deficiency 614025
    [High density lipoprotein cholesterol level QTL 12] 612797
    DISEASE ASSOCIATED WITH lipca VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to hormone (more)
    Cellular Component extracellular region (more)
    Molecular Function carboxylic ester hydrolase activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lipca-201 (1)    Ensembl 1923
    ncRNA lipca-002 (1)    Ensembl 1127
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lipca No data available
    MARKER RELATIONSHIPS
    lipca Contained in: [BAC] DKEY-261O24 (1) (order this)
    lipca Encodes: [cDNA] MGC:64081 (1), MGC:191138 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201022 (1) 1733 nt
    Genomic GenBank:BX957301 (1) 64006 nt
    Select Tool
    Polypeptide UniProtKB:F1QA22 (1) 514 aa
    Sequence Information (all 14)
    ORTHOLOGY for lipca ( Chr: 7 )
    CITATIONS (37)