Gene

lipca

ID
ZDB-GENE-040426-1361
Name
lipase, hepatic a
Symbol
lipca Nomenclature History
Previous Names
  • lipc
  • zgc:64081
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to enable apolipoprotein binding activity; lipoprotein lipase activity; and phospholipase activity. Acts upstream of or within response to hormone. Predicted to be located in extracellular region. Predicted to be part of high-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several structures, including heart; integument; lens; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; coronary artery disease; familial combined hyperlipidemia; peripheral vascular disease; and type 2 diabetes mellitus. Orthologous to human LIPC (lipase C, hepatic type).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lipca Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
type 2 diabetes mellitus Alliance {Diabetes mellitus, noninsulin-dependent} 125853
Hepatic lipase deficiency 614025
[High density lipoprotein cholesterol level QTL 12] 612797
Associated With lipca Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001024 PLAT/LH2 domain
Domain IPR013818 Lipase/vitellogenin
Domain IPR033906 Lipase, N-terminal
Family IPR000734 Triacylglycerol lipase family
Family IPR002333 Hepatic lipase
Family IPR016272 Lipase, LIPH-type
Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
Homologous_superfamily IPR036392 PLAT/LH2 domain superfamily
Domain Details Per Protein
Protein Length Alpha/Beta hydrolase fold Hepatic lipase Lipase, LIPH-type Lipase, N-terminal Lipase/vitellogenin PLAT/LH2 domain PLAT/LH2 domain superfamily Triacylglycerol lipase family
UniProtKB:F1QA22 514
UniProtKB:Q7T359 514
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations