ZFIN is now using GRCz12tu for Genomic Data
Gene
prkcba
- ID
- ZDB-GENE-040426-1354
- Name
- protein kinase C, beta a
- Symbol
- prkcba Nomenclature History
- Previous Names
-
- prkcb1l
- zgc:64063 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoplasm. Is expressed in several structures, including brain; forebrain neural keel; otic placode; pectoral fin musculature; and pronephros. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64063 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000008 | C2 domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR017892 | Protein kinase, C-terminal |
| Domain | IPR020454 | Diacylglycerol/phorbol-ester binding |
| Family | IPR014375 | Protein kinase C, alpha/beta/gamma types |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AGC-kinase, C-terminal | C1-like domain superfamily | C2 domain | C2 domain superfamily | Diacylglycerol/phorbol-ester binding | Protein kinase, ATP binding site | Protein kinase C, alpha/beta/gamma types | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein kinase, C-terminal | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T2C5 | InterPro | 668 | ||||||||||||
| UniProtKB:A0A8M2BI27 | InterPro | 667 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkcba-201
(1)
|
Ensembl | 2,481 nt | ||
| mRNA |
prkcba-202
(1)
|
Ensembl | 1,155 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers