Gene
myo1eb
- ID
- ZDB-GENE-040426-1347
- Name
- myosin IEb
- Symbol
- myo1eb Nomenclature History
- Previous Names
-
- zgc:64042
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have actin filament binding activity; actin-dependent ATPase activity; and microfilament motor activity. Involved in glomerular filtration and glomerulus development. Predicted to localize to several cellular components, including actin cytoskeleton; actin-based cell projection; and vesicle. Is expressed in several structures, including EVL; ectoderm; epidermis; peripheral olfactory organ; and pharynx. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Orthologous to human MYO1E (myosin IE).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64042 (22 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| focal segmental glomerulosclerosis 6 | Alliance | Glomerulosclerosis, focal segmental, 6 | 614131 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001609 | Myosin head, motor domain |
| Domain | IPR010926 | Class I myosin tail homology domain |
| Domain | IPR035507 | Unconventional myosin-Ie/If, SH3 domain |
| Domain | IPR036072 | Class I myosin, motor domain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | Class I myosin, motor domain | Class I myosin tail homology domain | Kinesin motor domain superfamily | Myosin head, motor domain | P-loop containing nucleoside triphosphate hydrolase | SH3 domain | SH3-like domain superfamily | Unconventional myosin-Ie/If, SH3 domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QJK0
|
1096 | ||||||||
|
UniProtKB:A0A2R8QAL9
|
1090 | ||||||||
|
UniProtKB:Q6PFT4
|
1096 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
myo1eb-201
(1)
|
4020 nt |
Interactions and Pathways
No data available
Plasmids
No data available