ZFIN ID: ZDB-GENE-040426-1339
Gene Name: hydroxysteroid (17-beta) dehydrogenase 3
Gene Symbol: hsd17b3    Nomenclature History

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Previous Name: zgc:64019 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Exhibits testosterone 17-beta-dehydrogenase (NADP+) activity. Involved in androgen biosynthetic process. Localizes to endoplasmic reticulum. Human ortholog(s) of this gene implicated in disorders of sexual development. Is expressed in digestive system; gonad; heart; immune system; and integument. Orthologous to human HSD17B3 (hydroxysteroid 17-beta dehydrogenase 3).
Genome Resources: Alliance (1),  Gene:393335 (1),  Ensembl(GRCz11):ENSDARG00000023287 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH hsd17b3 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Pseudohermaphroditism, male, with gynecomastia 264300
DISEASE ASSOCIATED WITH hsd17b3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process androgen biosynthetic process (more)
Cellular Component endoplasmic reticulum (more)
Molecular Function testosterone 17-beta-dehydrogenase (NADP+) activity (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA hsd17b3-201 (1)    Ensembl 2116
hsd17b3-203 (1)    Ensembl 2145
ncRNA hsd17b3-003 (1)    Ensembl 655
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM hsd17b3 No data available
MARKER RELATIONSHIPS
hsd17b3 Contained in: [BAC] CH211-248D20 (1)
hsd17b3 Encodes: [cDNA] MGC:64019 (1), MGC:193009 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_200364 (1) 2132 nt
Genomic GenBank:CR376747 (1) 153394 nt
Select Tool
Polypeptide UniProtKB:A0A2R8QE67 (1) 307 aa
Sequence Information (all 19)
ORTHOLOGY for hsd17b3 ( Chr: 8 )
CITATIONS (75)