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Gene

hsd17b3

ID
ZDB-GENE-040426-1339
Name
hydroxysteroid (17-beta) dehydrogenase 3
Symbol
hsd17b3 Nomenclature History
Previous Names
  • zgc:64019 (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Enables testosterone 17-beta-dehydrogenase (NADP+) activity. Acts upstream of or within androgen biosynthetic process. Located in endoplasmic reticulum. Is expressed in digestive system; gonad; heart; immune system; and integument. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency and disorder of sexual development. Orthologous to human HSD17B3 (hydroxysteroid 17-beta dehydrogenase 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hsd17b3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
17-beta hydroxysteroid dehydrogenase 3 deficiency Alliance Pseudohermaphroditism, male, with gynecomastia 264300
Associated With hsd17b3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020904 Short-chain dehydrogenase/reductase, conserved site
Family IPR002347 Short-chain dehydrogenase/reductase SDR
Family IPR033281 Testosterone 17-beta-dehydrogenase 3
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length NAD(P)-binding domain superfamily Short-chain dehydrogenase/reductase, conserved site Short-chain dehydrogenase/reductase SDR Testosterone 17-beta-dehydrogenase 3
UniProtKB:Q6QA32 307
UniProtKB:A0A2R8QE67 307
UniProtKB:Q7T396 236
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations