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ZIRC
ZFIN ID: ZDB-GENE-040426-1296
Gene Name: cytochrome P450, family 7, subfamily A, polypeptide 1
Gene Symbol: cyp7a1    Nomenclature History

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Previous Names: cyp7a1, cyp7a1a, zgc:63920 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have cholesterol 7-alpha-monooxygenase activity; heme binding activity; and iron ion binding activity. Predicted to be involved in bile acid biosynthetic process and cholesterol homeostasis. Predicted to localize to the endoplasmic reticulum; endoplasmic reticulum membrane; and integral component of membrane. Is expressed in basal plate midbrain region; central nervous system; otic vesicle; and retinal ganglion cell layer. Orthologous to human CYP7A1 (cytochrome P450 family 7 subfamily A member 1).
Genome Resources: Alliance (1),  Gene:394148 (1),  Ensembl(GRCz11):ENSDARG00000069018 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa19734 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32900 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32901 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38326 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf2169 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cyp7a1 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cyp7a1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cyp7a1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process bile acid biosynthetic process (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function cholesterol 7-alpha-monooxygenase activity (more)
    GO Terms (all 20)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cyp7a1-201 (1)    Ensembl 1987
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp7a1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(fabp10a:mcherry-2a-cyp7a1) fabp10a 2Acyp7a1mCherry Danio rerio 1 1
    MARKER RELATIONSHIPS
    cyp7a1 Contained in: [BAC] CH211-198J13 (1) (order this)
    cyp7a1 Encodes: [EST] eu2450 (1)
    [cDNA] MGC:63920 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_201173 (1) 3479 bp
    Genomic GenBank:CR450692 (1) 180976 bp
    Select Tool
    Polypeptide UniProtKB:F1QU76 (1) 512 aa
    Sequence Information (all 9)
    ORTHOLOGY for cyp7a1 ( Chr: 2 )
    CITATIONS (39)