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Gene

sox4b

ID
ZDB-GENE-040426-1274
Name
SRY-box transcription factor 4b
Symbol
sox4b Nomenclature History
Previous Names
  • zgc:63851
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within closure of optic fissure; endocrine pancreas development; and negative regulation of smoothened signaling pathway. Predicted to be located in nucleus. Is expressed in several structures, including basal plate midbrain region; central nervous system; integument; pancreatic system; and retina. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome and urinary bladder cancer. Orthologous to human SOX4 (SRY-box transcription factor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
24 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Mavropoulos et al., 2005
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sox4b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Coffin-Siris syndrome 10 618506
Associated With sox4b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR009071 High mobility group box domain
Family IPR017386 Transcription factor SOX-12/11/4
Homologous_superfamily IPR036910 High mobility group box domain superfamily
Domain Details Per Protein
Protein Length High mobility group box domain High mobility group box domain superfamily Transcription factor SOX-12/11/4
UniProtKB:A0A0R4IQD2 342
UniProtKB:Q6P2A2 342
UniProtKB:Q6UJB6 342
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations