Gene

ddb1

ID

ZDB-GENE-040426-1272

Name

damage-specific DNA binding protein 1

Symbol

ddb1 Nomenclature History

Previous Names

zgc:63840

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have damaged DNA binding activity. Involved in negative regulation of apoptotic process and regulation of cell cycle process. Predicted to localize to cullin-RING ubiquitin ligase complex and nucleus. Is expressed in blastomere; endoderm; nervous system; pharyngeal arch; and somite. Orthologous to human DDB1 (damage specific DNA binding protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Hu et al., 2015

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ddb1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		White-Kernohan syndrome	619426

Associated With ddb1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004871	Cleavage/polyadenylation specificity factor, A subunit, C-terminal
Domain	IPR018846	Cleavage/polyadenylation specificity factor, A subunit, N-terminal
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily