ZFIN ID: ZDB-GENE-040426-1263
Gene Name: calpain 1, (mu/I) large subunit a
Gene Symbol: capn1a    Nomenclature History

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Previous Names: capn1, zgc:63788

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have calcium-dependent cysteine-type endopeptidase activity. Involved in brain development and branchiomotor neuron axon guidance. Predicted to localize to the cytoplasm. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 76. Is expressed in brain. Orthologous to several human genes including CAPN11 (calpain 11).
Genome Resources: Alliance (1),  Gene:393417 (1),  Ensembl(GRCz11):ENSDARG00000052702 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:63788]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2687 Point Mutation Unknown Premature Stop ENU
sa42288 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-capn1a
    1
    MO1-capn1a N/A 1
    DISEASE ASSOCIATED WITH capn1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary spastic paraplegia 76 Alliance Spastic paraplegia 76, autosomal recessive 616907
    DISEASE ASSOCIATED WITH capn1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process brain development (more)
    Cellular Component cytoplasm (more)
    Molecular Function calcium-dependent cysteine-type endopeptidase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Active_site IPR000169 Cysteine peptidase, cysteine active site
    Binding_site IPR018247 EF-Hand 1, calcium-binding site
    Domain IPR001300 Peptidase C2, calpain, catalytic domain
    Domain IPR002048 EF-hand domain
    Domain IPR022682 Peptidase C2, calpain, large subunit, domain III
    Domain IPR022683 Peptidase C2, calpain, domain III
    Domain IPR033883 Calpain subdomain III
    Family IPR022684 Peptidase C2, calpain family
    Homologous_superfamily IPR011992 EF-hand domain pair
    Homologous_superfamily IPR036213 Calpain large subunit, domain III superfamily
    Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA capn1a-201 (1)    Ensembl 2983
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM capn1a No data available
    MARKER RELATIONSHIPS
    capn1a Contained in: [BAC] CH211-229O17 (1)
    capn1a Encodes: [cDNA] MGC:63788 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200445 (1) 2974 nt
    Genomic GenBank:BX936318 (1) 158912 nt
    Select Tool
    Polypeptide UniProtKB:B8A6G0 (1) 704 aa
    Sequence Information (all 11)
    ORTHOLOGY for capn1a ( Chr: 13 )
    CITATIONS (27)