ZFIN Gene: aldh2.1

ZFIN ID: ZDB-GENE-040426-1262

ZFIN ID: ZDB-GENE-040426-1262

Gene Name:

aldehyde dehydrogenase 2 family member, tandem duplicate 1

Gene Symbol:

aldh2.1 Nomenclature History

Previous Names:

aldh2 (1), aldh2a, zgc:63786

Gene Type:

protein_coding_gene

Location:

Chr: 5 Mapping Details/Browsers

Description:

Exhibits 3-chloroallyl aldehyde dehydrogenase activity. Predicted to be involved in cellular aldehyde metabolic process. Is expressed in several structures, including fin; heart; liver; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); diabetic neuropathy; and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member).

Genome Resources:

Alliance (1), Gene:393462 (1), Ensembl(GRCz11):ENSDARG00000089924 (2)

GENE EXPRESSION
All Expression Data:	3 figures from 3 publications
Wild-type Stages, Structures:	Cleavage:64-cell (2.0h-2.25h) to Adult (90d-730d, breeding adult)
	brain caudal fin eye gill heart intestine liver musculature system ovary pectoral fin swim bladder trunk musculature whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-aldh2.1	N/A	1

PHENOTYPE No data available

DISEASE ASSOCIATED WITH aldh2.1 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Alcohol sensitivity, acute	610251
		{Esophageal cancer, alcohol-related, susceptibility to}
		{Hangover, susceptibility to}	610251
		{Sublingual nitroglycerin, susceptibility to poor response to}

DISEASE ASSOCIATED WITH aldh2.1 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	cellular aldehyde metabolic process (more)
Cellular Component	cellular_component (more)
Molecular Function	3-chloroallyl aldehyde dehydrogenase activity (more)

GO Terms (all 7)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	aldh2.1-201 (1)	1935	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM aldh2.1 No data available

MARKER RELATIONSHIPS

aldh2.1 Contained in:	[BAC] CH211-157P22 (1), DKEY-204G14 (1) (order this)
aldh2.1 Encodes:	[cDNA] MGC:63786 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_200490 (1)	1940 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CT978957 (1)	164556 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A2BGR9 (1)	516 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 13)

ORTHOLOGY for aldh2.1 ( Chr: 5 )

CITATIONS (36)

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