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ZIRC
ZFIN ID: ZDB-GENE-040426-1262
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Gene Name: aldehyde dehydrogenase 2 family member, tandem duplicate 1
Gene Symbol: aldh2.1    Nomenclature History

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Previous Names: aldh2 (1), aldh2a, zgc:63786

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Exhibits 3-chloroallyl aldehyde dehydrogenase activity. Predicted to be involved in cellular aldehyde metabolic process. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); diabetic neuropathy; and liver disease (multiple). Is expressed in several structures, including fin; heart; liver; musculature system; and pleuroperitoneal region. Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member).
Genome Resources: Alliance (1),  Gene:393462 (1),  Ensembl(GRCz11):ENSDARG00000089924 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Cleavage:64-cell (2.0h-2.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-aldh2.1 N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH aldh2.1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Alcohol sensitivity, acute 610251
{Esophageal cancer, alcohol-related, susceptibility to}
{Hangover, susceptibility to} 610251
{Sublingual nitroglycerin, susceptibility to poor response to}
DISEASE ASSOCIATED WITH aldh2.1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cellular aldehyde metabolic process (more)
Cellular Component cellular_component (more)
Molecular Function 3-chloroallyl aldehyde dehydrogenase activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR015590 (1)
  • InterPro:IPR016160 (1)
  • InterPro:IPR016161 (1)
  • InterPro:IPR016162 (1)
  • InterPro:IPR016163 (1)
  • InterPro:IPR029510 (1)
  • PROSITE:PS00070 (1)
  • PROSITE:PS00687 (1)
  • Pfam:PF00171 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA aldh2.1-201 (1)    Ensembl 1935
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM aldh2.1 No data available
    MARKER RELATIONSHIPS
    aldh2.1 Contained in: [BAC] CH211-157P22 (1) (order this), DKEY-204G14 (1) (order this)
    aldh2.1 Encodes: [cDNA] MGC:63786 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200490 (1) 1940 bp
    Select Tool
    Genomic GenBank:CT978957 (1) 164556 bp
    Select Tool
    Polypeptide UniProtKB:A2BGR9 (1) 516 aa
    Select Tool
    Sequence Clusters UniGene:28434 (1)
    Sequence Information (all 14)
    ORTHOLOGY for aldh2.1 ( Chr: 5 )
    CITATIONS (34)