ZFIN ID: ZDB-GENE-040426-1261
Gene Name: 5'-nucleotidase, ecto (CD73)
Gene Symbol: nt5e    Nomenclature History

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Previous Name: zgc:63784

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have 5'-nucleotidase activity. Involved in response to copper ion. Predicted to localize to plasma membrane. Is expressed in brain and intestinal bulb. Human ortholog(s) of this gene implicated in hereditary arterial and articular multiple calcification syndrome. Orthologous to human NT5E (5'-nucleotidase ecto).
Genome Resources: Alliance (1),  Gene:393906 (1),  Ensembl(GRCz11):ENSDARG00000071017 (2)
GENE EXPRESSION
All Expression Data: 15 figures from 9 publications
Directly Submitted Expression Data: 7 figures (3 images) from Thisse et al., 2004 [MGC:63784]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028295Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa8734 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH nt5e HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary arterial and articular multiple calcification syndrome Alliance Calcification of joints and arteries 211800
    DISEASE ASSOCIATED WITH nt5e VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to copper ion (more)
    Cellular Component plasma membrane (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nt5e-201 (1)    Ensembl 2104
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nt5e No data available
    MARKER RELATIONSHIPS
    nt5e Contained in: [BAC] CH211-241P10
    nt5e Encodes: [cDNA] MGC:63784 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200932 (1) 2116 nt
    Genomic GenBank:BX537259 (1) 185460 nt
    Select Tool
    Polypeptide UniProtKB:Q5PNP4 (1) 571 aa
    Sequence Information (all 9)
    ORTHOLOGY for nt5e ( Chr: 20 )
    CITATIONS (43)