ZFIN ID: ZDB-GENE-040426-1254
Gene Name: low density lipoprotein receptor b
Gene Symbol: ldlrb    Nomenclature History

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Previous Name: zgc:63759

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor).
Genome Resources: Alliance (1),  Gene:393460 (1),  Ensembl(GRCz11):ENSDARG00000026759 (2)
GENE EXPRESSION
All Expression Data: Fig. S6 from Cho et al., 2019
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ldlrb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial hypercholesterolemia Alliance Hypercholesterolemia, familial, 1 143890
LDL cholesterol level QTL2 143890
DISEASE ASSOCIATED WITH ldlrb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process endocytosis (more)
Cellular Component integral component of membrane (more)
Molecular Function calcium ion binding (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
aberrant processed transcript ldlrb-202 (1)    Ensembl 838
mRNA ldlrb-201 (1)    Ensembl 2789
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ldlrb No data available
MARKER RELATIONSHIPS
ldlrb Contained in: [Fosmid] ZFOS-323E3 (1)
ldlrb Encodes: [cDNA] MGC:63759 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_200488 (1) 1730 nt
Genomic GenBank:CU693486 (1) 42264 nt
Select Tool
Polypeptide UniProtKB:K7DYA0 (1) 788 aa
Sequence Information (all 13)
ORTHOLOGY for ldlrb ( Chr: 6 )
CITATIONS (15)