ZFIN ID: ZDB-GENE-040426-1244
Gene Name: arginyl-tRNA synthetase 2, mitochondrial
Gene Symbol: rars2    Nomenclature History

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Previous Name: zgc:63702

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have arginine-tRNA ligase activity. Involved in brain morphogenesis. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 6. Orthologous to human RARS2 (arginyl-tRNA synthetase 2, mitochondrial).
Genome Resources: Alliance (1),  Gene:393589 (1),  Ensembl(GRCz11):ENSDARG00000032277 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:63702]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa17180 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-rars2 N/A 1
    MO2-rars2 N/A 1
    DISEASE ASSOCIATED WITH rars2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    pontocerebellar hypoplasia type 6 Alliance Pontocerebellar hypoplasia, type 6 611523
    DISEASE ASSOCIATED WITH rars2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process brain morphogenesis (more)
    Cellular Component cytoplasm (more)
    Molecular Function aminoacyl-tRNA ligase activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript rars2-203 (1)    Ensembl 882
    mRNA rars2-201 (1)    Ensembl 1942
    rars2-202 (1)    Ensembl 881
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rars2 No data available
    MARKER RELATIONSHIPS
    rars2 Contained in: [BAC] CH73-317M8 (1)
    [Fosmid] CH1073-493K20 (1)
    rars2 Encodes: [cDNA] MGC:63702 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200617 (1) 1928 nt
    Genomic GenBank:CT573058 (1) 108787 nt
    Select Tool
    Polypeptide UniProtKB:A5WVY0 (1) 597 aa
    Sequence Information (all 15)
    ORTHOLOGY for rars2 ( Chr: 20 )
    CITATIONS (19)