Gene

rars2

ID
ZDB-GENE-040426-1244
Name
arginyl-tRNA synthetase 2, mitochondrial
Symbol
rars2 Nomenclature History
Previous Names
  • zgc:63702
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable arginine-tRNA ligase activity. Acts upstream of or within brain morphogenesis. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 6. Orthologous to human RARS2 (arginyl-tRNA synthetase 2, mitochondrial).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Kasher et al., 2011
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rars2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
pontocerebellar hypoplasia type 6 Alliance Pontocerebellar hypoplasia, type 6 611523
Associated With rars2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
Domain IPR008909 DALR anticodon binding
Domain IPR035684 Arginyl-tRNA synthetase, catalytic core domain
Family IPR001278 Arginine-tRNA ligase
Homologous_superfamily IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Homologous_superfamily IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily IPR036695 Arginyl tRNA synthetase N-terminal domain superfamily
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class Ia, anticodon-binding Aminoacyl-tRNA synthetase, class I, conserved site Arginine-tRNA ligase Arginyl-tRNA synthetase, catalytic core domain Arginyl tRNA synthetase N-terminal domain superfamily DALR anticodon binding Rossmann-like alpha/beta/alpha sandwich fold
UniProtKB:R4GEI8 113
UniProtKB:A5WVY0 597
UniProtKB:A5WVY1 221
UniProtKB:Q6PGW8 597
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations