ZFIN ID: ZDB-GENE-040426-1225
Gene Name: relaxin family peptide receptor 2a
Gene Symbol: rxfp2a    Nomenclature History

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Previous Names: rxfp2, rxfp2b, zgc:63668

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have G protein-coupled peptide receptor activity. Predicted to be involved in activation of adenylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; and hormone-mediated signaling pathway. Predicted to localize to the integral component of plasma membrane. Human ortholog(s) of this gene implicated in cryptorchidism. Is expressed in female organism; male organism; and ovary. Orthologous to human RXFP2 (relaxin family peptide receptor 2).
Genome Resources: Alliance (1),  Gene:792884 (1),  Ensembl(GRCz11):ENSDARG00000032820 (1)
Note: In March of 2012 this gene was found to be orthologous (both AA and synteny) to human and mouse RXFP2. The curator named this gene rxfp2b, in accordance with Zebrafish Nomenclature Guidelines. In the same month, Yegorov and Good (2012) named this gene rxpfa. Subsequently, two additional publications have maintained Yegorov and Good's nomenclature. In November of 2015 the names and gene symbols of both paralogs were changed to reflect a request filed with NCBI that was forwarded to the ZFIN nomenclature coordinator.
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa4378 Point Mutation Unknown Premature Stop ENU
sa12070 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13851 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34944 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH rxfp2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH rxfp2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process G protein-coupled receptor signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function G protein-coupled receptor activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000276 G protein-coupled receptor, rhodopsin-like
    Repeat IPR001611 Leucine-rich repeat
    Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    Repeat IPR003591 Leucine-rich repeat, typical subtype
    Family IPR008112 Relaxin receptor
    Domain IPR017452 GPCR, rhodopsin-like, 7TM
    Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
    Homologous_superfamily IPR036055 LDL receptor-like superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rxfp2a-201 (1)    Ensembl 2900
    rxfp2a-202 (1)    Ensembl 2265
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rxfp2a No data available
    MARKER RELATIONSHIPS
    rxfp2a Contained in: [BAC] DKEY-159F4 (1) (order this), DKEYP-10A10 (1)
    rxfp2a Encodes: [cDNA] MGC:63668 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200443 (1) 2293 bp
    Genomic GenBank:BX569785 (1) 140734 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R3P9B9 (1) 754 aa
    Sequence Information (all 18)
    ORTHOLOGY for rxfp2a ( Chr: 10 )
    CITATIONS (21)