ZFIN ID: ZDB-GENE-040426-1224
Gene Name: cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 4
Gene Symbol: cyp46a1.4    Nomenclature History

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Previous Names: cyp46a4, zgc:63667

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have cholesterol 24-hydroxylase activity and heme binding activity. Predicted to be involved in cholesterol catabolic process. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CYP46A1 (cytochrome P450 family 46 subfamily A member 1).
Genome Resources: Alliance (1),  Gene:393451 (1),  Ensembl(GRCz11):ENSDARG00000113820 (1)
GENE EXPRESSION
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa36958 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cyp46a1.4 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cyp46a1.4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cholesterol catabolic process (more)
    Molecular Function cholesterol 24-hydroxylase activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR001128 Cytochrome P450
    Family IPR002401 Cytochrome P450, E-class, group I
    Homologous_superfamily IPR036396 Cytochrome P450 superfamily
    Family IPR039983 Cholesterol 24-hydroxylase
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp46a1.4 No data available
    MARKER RELATIONSHIPS
    cyp46a1.4 Encodes: [cDNA] MGC:63667 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200479 (1) 1869 bp
    Genomic GenBank:CABZ01045950 (1) 13524 bp
    Polypeptide UniProtKB:A0A0N4SUD5 (1) 501 aa
    Sequence Information (all 12)
    ORTHOLOGY for cyp46a1.4 ( Chr: 20 )
    CITATIONS (16)