Gene

cdc14aa

ID

ZDB-GENE-040426-1214

Name

cell division cycle 14Aa

Symbol

cdc14aa Nomenclature History

Previous Names

cdc14a1 (1)
zgc:63654 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Involved in cilium assembly. Localizes to centrosome and spindle pole. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 32. Is expressed in Kupffer's vesicle; forerunner cell group; nervous system; neural tube; and pronephric duct. Orthologous to human CDC14A (cell division cycle 14A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:63654 (18 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cdc14aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 32	Alliance	Deafness, autosomal recessive 32, with or without immotile sperm	608653

Associated With cdc14aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR016130	Protein-tyrosine phosphatase, active site
Domain	IPR000340	Dual specificity phosphatase, catalytic domain
Domain	IPR000387	Tyrosine-specific protein phosphatases domain
Domain	IPR020422	Dual specificity protein phosphatase domain
Domain	IPR029260	Dual specificity/tyrosine protein phosphatase, N-terminal
Domain	IPR044506	Dual-specificity phosphatase CDC14, C-terminal
Homologous_superfamily	IPR029021	Protein-tyrosine phosphatase-like