ZFIN ID: ZDB-GENE-040426-1205
Gene Name: xeroderma pigmentosum, complementation group A
Gene Symbol: xpa    Nomenclature History

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Previous Name: zgc:63640

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have damaged DNA binding activity. Predicted to be involved in DNA repair. Predicted to localize to nucleotide-excision repair factor 1 complex. Is expressed in liver. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group A. Orthologous to human XPA (XPA, DNA damage recognition and repair factor).
Genome Resources: Alliance (1),  Gene:393443 (1),  Ensembl(GRCz11):ENSDARG00000038114 (2)
GENE EXPRESSION
All Expression Data: Fig. 5 from Notch et al., 2007
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020974Tg Transgenic Insertion Unknown Unknown DNA
sa16787 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38250 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko255a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • zko255b Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-xpa 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH xpa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    xeroderma pigmentosum group A Alliance Xeroderma pigmentosum, group A 278700
    DISEASE ASSOCIATED WITH xpa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular response to DNA damage stimulus (more)
    Cellular Component host cell nucleus (more)
    Molecular Function damaged DNA binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA xpa-201 (1)    Ensembl 1793
    ncRNA xpa-003 (1)    Ensembl 749
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM xpa No data available
    MARKER RELATIONSHIPS
    xpa Contained in: [BAC] DKEY-58J15 (1) (order this)
    xpa Encodes: [cDNA] MGC:63640 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200471 (1) 1797 nt
    Genomic GenBank:BX908747 (1) 232503 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1R092 (1) 549 aa
    Sequence Information (all 15)
    ORTHOLOGY for xpa ( Chr: 1 )
    CITATIONS (31)