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ZIRC
ZFIN ID: ZDB-GENE-040426-1158
Gene Name: protein tyrosine phosphatase non-receptor type 11b
Gene Symbol: ptpn11b
Sequence Ontology ID : SO:0000704

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Attributions

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Previous Names: SHP3 (1), zgc:63553

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(Including Attributions)
Location: Chr: 23 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits phosphatase activity. Involved in MAPK cascade; cell population proliferation; and embryonic viscerocranium morphogenesis. Predicted to localize to the cytoplasm. Human ortholog(s) of this  ...
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Blastula:Sphere (4.0h-4.33h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu5920 Point Mutation Exon 3 Premature Stop ENU
la028516Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa7505 Point Mutation Unknown Missense ENU
    sa11037 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11510 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37695 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45799 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ptpn11b HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    juvenile myelomonocytic leukemia Leukemia, juvenile myelomonocytic, somatic 607785
    LEOPARD syndrome LEOPARD syndrome 1 151100
    Noonan syndrome 1 Noonan syndrome 1 163950
    Metachondromatosis 156250
    DISEASE ASSOCIATED WITH ptpn11b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell population proliferation (more)
    Cellular Component cytoplasm (more)
    Molecular Function phosphatase activity (more)
    GO Terms (all 10)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ptpn11b-201 (1) 3241
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM ptpn11b No data available
    MARKER RELATIONSHIPS
    ptpn11bContained in: [BAC] CH211-203J19 (1) (order this), DKEY-196B15 (1) (order this)
    ptpn11bEncodes: [cDNA] MGC:63553 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200454 (1) 3246bp
    Genomic GenBank:CR450795 (1) 162230bp
    Select Tool
    Polypeptide UniProtKB:F1R1Z7 (1) 592aa
    Sequence Clusters UniGene:13952 (1)
    Sequence Information (all 22)
    ORTHOLOGY for ptpn11b (Chr: 23)
    CITATIONS (28)