ZFIN ID: ZDB-GENE-040426-1152
Gene Name: argininosuccinate lyase
Gene Symbol: asl    Nomenclature History

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Previous Name: zgc:63532 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have argininosuccinate lyase activity. Predicted to be involved in arginine biosynthetic process via ornithine. Predicted to localize to the cytoplasm. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and argininosuccinic aciduria. Is expressed in several structures, including ball; lens; liver; pronephric duct; and solid lens vesicle. Orthologous to human ASL (argininosuccinate lyase).
Genome Resources: Alliance (1),  Gene:393423 (1),  Ensembl(GRCz11):ENSDARG00000033361 (2)
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 6 figures (6 images) from Thisse et al., 2004 [MGC:63532]
Wild-type Stages, Structures: Cleavage:32-cell (1.75h-2.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12812 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13022 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH asl HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    argininosuccinic aciduria Alliance Argininosuccinic aciduria 207900
    DISEASE ASSOCIATED WITH asl VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process arginine biosynthetic process via ornithine (more)
    Cellular Component cytoplasm (more)
    Molecular Function argininosuccinate lyase activity (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR020557 Fumarate lyase, conserved site
    Domain IPR022761 Fumarate lyase, N-terminal
    Domain IPR029419 Argininosuccinate lyase, C-terminal
    Family IPR000362 Fumarate lyase family
    Family IPR009049 Argininosuccinate lyase
    Homologous_superfamily IPR008948 L-Aspartase-like
    Homologous_superfamily IPR024083 Fumarase/histidase, N-terminal
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA asl-201 (1)    Ensembl 1811
    asl-202 (1)    Ensembl 835
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM asl No data available
    MARKER RELATIONSHIPS
    asl Contained in: [BAC] DKEY-225F3 (1) (order this)
    asl Encodes: [cDNA] MGC:63532 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200451 (1) 1809 nt
    Genomic GenBank:CR450753 (1) 160631 nt
    Select Tool
    Polypeptide UniProtKB:F1RA91 (1) 465 aa
    Sequence Information (all 12)
    ORTHOLOGY for asl ( Chr: 21 )
    CITATIONS (23)