Gene

asl

ID
ZDB-GENE-040426-1152
Name
argininosuccinate lyase
Symbol
asl Nomenclature History
Previous Names
  • zgc:63532 (1)
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have argininosuccinate lyase activity. Predicted to be involved in arginine biosynthetic process via ornithine. Predicted to localize to cytosol. Is expressed in several structures, including ball; lens; liver; pronephric duct; and solid lens vesicle. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and argininosuccinic aciduria. Orthologous to human ASL (argininosuccinate lyase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With asl Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
argininosuccinic aciduria Alliance Argininosuccinic aciduria 207900
Associated With asl Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020557 Fumarate lyase, conserved site
Domain IPR022761 Fumarate lyase, N-terminal
Domain IPR029419 Argininosuccinate lyase, C-terminal
Family IPR000362 Fumarate lyase family
Family IPR009049 Argininosuccinate lyase
Homologous_superfamily IPR008948 L-Aspartase-like
Homologous_superfamily IPR024083 Fumarase/histidase, N-terminal
Domain Details Per Protein
Protein Length Argininosuccinate lyase Argininosuccinate lyase, C-terminal Fumarase/histidase, N-terminal Fumarate lyase, conserved site Fumarate lyase family Fumarate lyase, N-terminal L-Aspartase-like
UniProtKB:E9QEZ3 240
UniProtKB:Q7SY44 465
UniProtKB:F1RA91 465
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations