ZFIN ID: ZDB-GENE-040426-1119
Gene Name: adaptor related protein complex 1 subunit sigma 1
Gene Symbol: ap1s1    Nomenclature History

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Previous Names: zgc:56704, zgc:85689

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Involved in extracellular matrix organization and nervous system development. Localizes to the perinuclear region of cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in MEDNIK syndrome. Is expressed in several structures, including hatching gland; nervous system; polster; pronephric duct; and solid lens vesicle. Orthologous to human AP1S1 (adaptor related protein complex 1 subunit sigma 1).
Genome Resources: Alliance (1),  Gene:393279 (1),  Ensembl(GRCz11):ENSDARG00000056803 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la016052Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ap1s1 N/A 2
    MO2-ap1s1 N/A 2
    DISEASE ASSOCIATED WITH ap1s1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    MEDNIK syndrome Alliance MEDNIK syndrome 609313
    DISEASE ASSOCIATED WITH ap1s1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process extracellular matrix organization (more)
    Cellular Component perinuclear region of cytoplasm (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR000804 Clathrin adaptor complex, small chain
    Homologous_superfamily IPR011012 Longin-like domain superfamily
    Family IPR016635 Adaptor protein complex, sigma subunit
    Domain IPR022775 AP complex, mu/sigma subunit
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ap1s1-201 (1)    Ensembl 807
    ap1s1-202 (1)    Ensembl 1727
    ap1s1-203 (1)    Ensembl 774
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ap1s1 No data available
    MARKER RELATIONSHIPS
    ap1s1 Contained in: [BAC] CH211-196F2 (1)
    ap1s1 Encodes: [cDNA] MGC:56704 (1), MGC:85689 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200309 (1) 1521 bp
    Genomic GenBank:BX470232 (1) 194721 bp
    Select Tool
    Polypeptide UniProtKB:A0A1D5NSU3 (1) 159 aa
    Sequence Information (all 20)
    ORTHOLOGY for ap1s1 ( Chr: 7 )
    CITATIONS (30)