ZFIN ID: ZDB-GENE-040426-1116
Gene Name: SBDS ribosome maturation factor
Gene Symbol: sbds    Nomenclature History

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Previous Name: zgc:56700 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Involved in exocrine pancreas development; granulocyte differentiation; and ribosome biogenesis. Used to study Shwachman-Diamond syndrome. Human ortholog(s) of this gene implicated in Shwachman-Diamond syndrome; aplastic anemia; exocrine pancreatic insufficiency; and hematopoietic system disease. Is expressed in gut; liver; pancreas; and pharyngeal arch 3-7. Orthologous to human SBDS (SBDS ribosome maturation factor).
Genome Resources: Alliance (1),  Gene:394096 (1),  Ensembl(GRCz11):ENSDARG00000027803 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7141500]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa331 Point Mutation Unknown Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-sbds N/A 1
MO2-sbds N/A 1
MO3-sbds N/A 1
MO4-sbds N/A 1
MO5-sbds N/A 1
DISEASE ASSOCIATED WITH sbds HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
aplastic anemia Alliance {Aplastic anemia, susceptibility to} 609135
Shwachman-Diamond syndrome Alliance Shwachman-Diamond syndrome 260400
GENE ONTOLOGY
Ontology GO Term
Biological Process exocrine pancreas development (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR002140 Ribosome maturation protein Sdo1/SBDS
Conserved_site IPR018023 Ribosome maturation protein SBDS, conserved site
Domain IPR018978 Ribosome maturation protein SBDS, C-terminal
Domain IPR019783 Ribosome maturation protein SBDS, N-terminal
Homologous_superfamily IPR036786 Ribosome maturation protein SBDS, N-terminal domain superfamily
Homologous_superfamily IPR037188 Ribosome maturation protein Sdo1/SBDS, central domain superfamily
Family IPR039100 Ribosome maturation protein Sdo1/SBDS-like
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA sbds-201 (1)    Ensembl 974
sbds-202 (1)    Ensembl 1461
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
CONSTRUCTS WITH SEQUENCES FROM sbds No data available
MARKER RELATIONSHIPS
sbds Contained in: [Fosmid] ZFOS-2415A2 (1)
sbds Encodes: [EST] IMAGE:7141500 (1)
[cDNA] MGC:56700 (1), MGC:174541 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_201121 (1) 1401 bp
Genomic GenBank:CU914374 (1) 29670 bp
Select Tool
Polypeptide UniProtKB:F8W5Q9 (1) 257 aa
Sequence Information (all 14)
ORTHOLOGY for sbds ( Chr: 15 )
CITATIONS (22)