ZFIN ID: ZDB-GENE-040426-1086
Gene Name: phosphatidylinositol glycan anchor biosynthesis, class A
Gene Symbol: piga    Nomenclature History

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Previous Names: im:6911675, zgc:56589 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have phosphatidylinositol N-acetylglucosaminyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to localize to glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 2 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGA (phosphatidylinositol glycan anchor biosynthesis class A).
Genome Resources: Alliance (1),  Gene:791759 (1),  Ensembl(GRCz11):ENSDARG00000041040 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6911675]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa41449 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH piga HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    multiple congenital anomalies-hypotonia-seizures syndrome 2 Alliance Multiple congenital anomalies-hypotonia-seizures syndrome 2 300868
    paroxysmal nocturnal hemoglobinuria Alliance Paroxysmal nocturnal hemoglobinuria, somatic 300818
    DISEASE ASSOCIATED WITH piga VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process GPI anchor biosynthetic process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function phosphatidylinositol N-acetylglucosaminyltransferase activity (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA piga-201 (1)    Ensembl 2401
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM piga No data available
    MARKER RELATIONSHIPS
    piga Contained in: [BAC] DKEY-18P12 (1) (order this)
    piga Encodes: [EST] IMAGE:6911675 (1)
    [cDNA] MGC:56589 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001126446 (1)
    Genomic GenBank:BX571845 (1) 106944 nt
    Select Tool
    Polypeptide UniProtKB:B0S6Z8 (1) 487 aa
    Sequence Information (all 13)
    ORTHOLOGY for piga ( Chr: 9 )
    CITATIONS (20)