Gene

piga

ID
ZDB-GENE-040426-1086
Name
phosphatidylinositol glycan anchor biosynthesis, class A
Symbol
piga Nomenclature History
Previous Names
  • im:6911675
  • zgc:56589 (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have phosphatidylinositol N-acetylglucosaminyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to localize to glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 2 and paroxysmal nocturnal hemoglobinuria. Orthologous to human PIGA (phosphatidylinositol glycan anchor biosynthesis class A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With piga Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
multiple congenital anomalies-hypotonia-seizures syndrome 2 Alliance Multiple congenital anomalies-hypotonia-seizures syndrome 2 300868
paroxysmal nocturnal hemoglobinuria Alliance Paroxysmal nocturnal hemoglobinuria, somatic 300818
Neurodevelopmental disorder with epilepsy and hemochromatosis 301072
Associated With piga Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001296 Glycosyl transferase, family 1
Domain IPR013234 PIGA, GPI anchor biosynthesis
Family IPR039507 Phosphatidylinositol N-acetylglucosaminyltransferase subunit PIG-A/GPI3
Domain Details Per Protein
Protein Length Glycosyl transferase, family 1 Phosphatidylinositol N-acetylglucosaminyltransferase subunit PIG-A/GPI3 PIGA, GPI anchor biosynthesis
UniProtKB:B0S6Z8 487
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA piga-201 (1) Havana 2401 nt
mRNA piga-202 (1) Ensembl 3353 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations