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Gene

chuk

ID
ZDB-GENE-040426-1069
Name
component of inhibitor of nuclear factor kappa B kinase complex
Symbol
chuk Nomenclature History
Previous Names
  • ikk1 (1)
  • IKKa (1)
  • pky
  • zgc:56539
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable protein heterodimerization activity; protein homodimerization activity; and protein serine/threonine kinase activity. Predicted to contribute to IkappaB kinase activity. Acts upstream of or within several processes, including epiboly involved in gastrulation with mouth forming second; negative regulation of I-kappaB kinase/NF-kappaB signaling; and somite specification. Predicted to be located in nucleus. Predicted to be part of IkappaB kinase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including immature eye; nervous system; notochord; pectoral fin; and segmental plate. Human ortholog(s) of this gene implicated in fetal encasement syndrome and prostate cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Fukazawa et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With chuk Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
fetal encasement syndrome Alliance Cocoon syndrome 613630
?Popliteal pterygium syndrome, Bartsocas-Papas type 2 619339
Associated With chuk Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR022007 I-kappa-kinase-beta NEMO binding domain
Domain IPR041185 IKBKB, scaffold dimerization domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length I-kappa-kinase-beta NEMO binding domain IKBKB, scaffold dimerization domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:A0A2R8Q1P1 788
UniProtKB:A0A2R8QI37 801
UniProtKB:B8JIH4 758
UniProtKB:Q4G3H4 758
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations