Gene

chuk

ID
ZDB-GENE-040426-1069
Name
component of inhibitor of nuclear factor kappa B kinase complex
Symbol
chuk Nomenclature History
Previous Names
  • ikk1 (1)
  • IKKa (1)
  • pky
  • zgc:56539
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to contribute to IkappaB kinase activity. Involved in several processes, including I-kappaB kinase/NF-kappaB signaling; epiboly involved in gastrulation with mouth forming second; and somite specification. Predicted to localize to IkappaB kinase complex. Human ortholog(s) of this gene implicated in cocoon syndrome and prostate cancer. Is expressed in several structures, including immature eye; nervous system; notochord; pectoral fin; and segmental plate. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Fukazawa et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With chuk Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
fetal encasement syndrome Alliance Cocoon syndrome 613630
?Popliteal pterygium syndrome, Bartsocas-Papas type 2 619339
Associated With chuk Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR022007 I-kappa-kinase-beta NEMO binding domain
Domain IPR041185 IKBKB, scaffold dimerization domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length I-kappa-kinase-beta NEMO binding domain IKBKB, scaffold dimerization domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:A0A2R8Q1P1 788
UniProtKB:A0A2R8QI37 801
UniProtKB:B8JIH4 758
UniProtKB:Q4G3H4 758
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations