ZFIN ID: ZDB-GENE-040426-1046
Gene Name: VRK serine/threonine kinase 2
Gene Symbol: vrk2    Nomenclature History

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Previous Names: vrk, zgc:56483

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Predicted to be involved in Wnt signaling pathway and peptidyl-serine phosphorylation. Predicted to localize to cytoplasm and nucleus. Orthologous to human VRK2 (VRK serine/threonine kinase 2).
Genome Resources: Alliance (1),  Gene:394145 (1),  Ensembl(GRCz11):ENSDARG00000021547 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a363 Complex Unknown Unknown CRISPR
sa35496 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-vrk2 1
    MO1-vrk2 N/A 1
    PHENOTYPE
    Data: 2 figures from Thyme et al., 2019
    Observed in:
    DISEASE ASSOCIATED WITH vrk2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH vrk2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphorylation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA vrk2-201 (1)    Ensembl 2147
    ncRNA vrk2-002 (1)    Ensembl 701
    vrk2-003 (1)    Ensembl 702
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM vrk2 No data available
    MARKER RELATIONSHIPS
    vrk2 Contained in: [BAC] DKEY-173F1 (1) (order this)
    vrk2 Encodes: [cDNA] MGC:56483 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201170 (1) 2109 nt
    Genomic GenBank:CR354594 (1) 196408 nt
    Select Tool
    Polypeptide UniProtKB:B8JHS7 (1) 574 aa
    Sequence Information (all 12)
    ORTHOLOGY for vrk2 ( Chr: 13 )
    CITATIONS (20)