ZFIN ID: ZDB-GENE-040426-1016
Gene Name: myotubularin related protein 8
Gene Symbol: mtmr8    Nomenclature History

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Previous Names: si:dkey-286f3.1, zgc:56405

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Exhibits MAP kinase kinase activity. Involved in blood vessel development and phosphatidylinositol 3-kinase signaling. Predicted to localize to the nuclear envelope. Is expressed in several structures, including anterior axial hypoblast; immature eye; optic primordium; vasculature; and ventral mesoderm. Orthologous to human MTMR8 (myotubularin related protein 8).
Genome Resources: Alliance (1),  Gene:393365 (1),  Ensembl(GRCz11):ENSDARG00000008592 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-mtmr8 N/A 2
MO2-mtmr8 N/A 2
DISEASE ASSOCIATED WITH mtmr8 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH mtmr8 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process blood vessel development (more)
Cellular Component nucleus (more)
Molecular Function MAP kinase kinase activity (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Active_site IPR016130 Protein-tyrosine phosphatase, active site
Domain IPR003595 Protein-tyrosine phosphatase, catalytic
Domain IPR010569 Myotubularin-like phosphatase domain
Family IPR030564 Myotubularin family
Family IPR030591 Myotubularin-related protein 8
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR029021 Protein-tyrosine phosphatase-like
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA mtmr8-201 (1)    Ensembl 3126
ncRNA mtmr8-002 (1)    Ensembl 633
mtmr8-003 (1)    Ensembl 533
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM mtmr8 No data available
MARKER RELATIONSHIPS
mtmr8 Contained in: [BAC] DKEY-286F3 (1) (order this)
mtmr8 Encodes: [cDNA] MGC:56405 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_200394 (1) 2354 nt
Genomic GenBank:CR812469 (1) 162086 nt
Select Tool
Polypeptide UniProtKB:Q6TEL0 (1) 632 aa
Sequence Information (all 13)
ORTHOLOGY for mtmr8 ( Chr: 5 )
CITATIONS (22)