Gene
sigmar1
- ID
- ZDB-GENE-040426-1006
- Name
- sigma non-opioid intracellular receptor 1
- Symbol
- sigmar1 Nomenclature History
- Previous Names
-
- oprs1
- zgc:56378 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Involved in response to wounding. Predicted to localize to endoplasmic reticulum and integral component of membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 16 and distal spinal muscular atrophy 2. Orthologous to human SIGMAR1 (sigma non-opioid intracellular receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56378 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 16 | Alliance | ?Amyotrophic lateral sclerosis 16, juvenile | 614373 |
| autosomal recessive distal hereditary motor neuronopathy 2 | Alliance | ?Neuronopathy, distal hereditary motor, autosomal recessive 2 | 605726 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR006716 | ERG2/sigma1 receptor-like |
Domain Details Per Protein
| Protein | Length | ERG2/sigma1 receptor-like |
|---|---|---|
|
UniProtKB:Q7ZWG9
|
222 | |
|
UniProtKB:A0A8M3B632
|
124 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sigmar1-201
(1)
|
Ensembl | 1,154 nt |
Interactions and Pathways
No data available
Plasmids
No data available