ZFIN ID: ZDB-GENE-040421-1
Gene Name: hydroxysteroid (17-beta) dehydrogenase 4
Gene Symbol: hsd17b4    Nomenclature History

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Previous Names: Dbp (1), zgc:55545, zgc:77300

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have oxidoreductase activity. Involved in embryonic organ development and neuron development. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4).
Genome Resources: Alliance (1),  Gene:393105 (1),  Ensembl(GRCz11):ENSDARG00000101239 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:77300]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 4 (96.0h-120.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-hsd17b4 N/A 1
MO2-hsd17b4 N/A 1
DISEASE ASSOCIATED WITH hsd17b4 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
D-bifunctional protein deficiency Alliance D-bifunctional protein deficiency 261515
Perrault syndrome Alliance Perrault syndrome 1 233400
DISEASE ASSOCIATED WITH hsd17b4 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process embryonic organ development (more)
Molecular Function oxidoreductase activity (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM hsd17b4 No data available
MARKER RELATIONSHIPS
hsd17b4 Encodes: [cDNA] MGC:55545 (1), MGC:77300 (1), MGC:192741 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_200136 (1)
Genomic GenBank:AF439317 (1) 4660 nt
Polypeptide UniProtKB:Q6NZW5 (1) 725 aa
Sequence Information (all 29)
ORTHOLOGY for hsd17b4 ( Chr: 8 )
CITATIONS (19)