ZFIN ID: ZDB-GENE-040420-2
Gene Name: nephrosin
Gene Symbol: npsn    Nomenclature History

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Previous Names: npsnl, ZC6AST2 (1), zgc:110470, zgc:152831

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have metalloendopeptidase activity. Involved in defense response to bacterium. Is expressed in hematopoietic cell and hematopoietic system. Orthologous to human ASTL (astacin like metalloendopeptidase).
Genome Resources: Alliance (1),  Gene:404039 (1),  Ensembl(GRCz11):ENSDARG00000010423 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12159 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15667 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34128 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40960 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sm15 Small Deletion Exon 5 Frameshift CRISPR
    sm16 Insertion Exon 6 Frameshift CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-npsn 1
    MO1-npsn N/A 1
    PHENOTYPE
    Data: Fig. 2 from Di et al., 2017
    Observed in:
    DISEASE ASSOCIATED WITH npsn HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH npsn VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process defense response to bacterium (more)
    Cellular Component cellular_component (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA npsn-201 (1)    Ensembl 1385
    npsn-202 (1)    Ensembl 919
    npsn-203 (1)    Ensembl 922
    ncRNA npsn-004 (1)    Ensembl 864
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM npsn
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:MYC-npsn) hsp70l MYCnpsn Danio rerio 1 1
    Tg(npsn:EGFP) npsn EGFP Danio rerio 1 1
    Tg(npsn:GFP) npsn GFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    npsn Contained in: [BAC] DKEY-150L7 (1) (order this)
    npsn Encodes: [cDNA] MGC:110470 (1), MGC:152831 (1), MGC:158184 (1), MGC:192017 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001077779 (1) 1379 nt
    Genomic GenBank:BX957297 (1) 79980 nt
    Select Tool
    Polypeptide UniProtKB:F1REP3 (1) 280 aa
    Sequence Information (all 33)
    ORTHOLOGY for npsn ( Chr: 7 )
    CITATIONS (35)