Gene

mttp

ID
ZDB-GENE-040419-2
Name
microsomal triglyceride transfer protein
Symbol
mttp Nomenclature History
Previous Names
  • mtp (1)
  • stalactite (1)
  • stl (1)
  • wu:fd36b01 (1)
  • zgc:111876
  • zgc:136353
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have phospholipid transporter activity. Involved in several processes, including fatty acid transport; lipoprotein biosynthetic process; and sprouting angiogenesis. Predicted to localize to Golgi apparatus; basolateral plasma membrane; and endoplasmic reticulum. Is expressed in several structures, including gut; liver; marginal blastomere; testis; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including abdominal obesity-metabolic syndrome 1; abetalipoproteinemia; familial hypercholesterolemia; hyperinsulinism; and obesity. Orthologous to human MTTP (microsomal triglyceride transfer protein).
Genome Resources
Note
None
Expression
All Expression Data
18 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mttp Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
abdominal obesity-metabolic syndrome 1 Alliance {Metabolic syndrome, protection against} 605552
abetalipoproteinemia Alliance Abetalipoproteinemia 200100
Associated With mttp Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR039988 Microsomal triglyceride transfer protein large subunit
Domain Details Per Protein
Protein Length Microsomal triglyceride transfer protein large subunit
UniProtKB:F1QGT1 106
UniProtKB:A0A0R4IVV0 884
UniProtKB:Q1JQ23 123
UniProtKB:Q502S3 195
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations