ZFIN ID: ZDB-GENE-040413-1
Gene Name: eukaryotic translation initiation factor 4ea
Gene Symbol: eif4ea    Nomenclature History

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Previous Names: eif4E-1A (1), eif4e1a, eif4e, zgc:86680

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Exhibits RNA 7-methylguanosine cap binding activity and translation initiation factor activity. Involved in translational initiation. Localizes to the cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EIF4E (eukaryotic translation initiation factor 4E).
Genome Resources: Alliance (1),  Gene:79380 (1),  Ensembl(GRCz11):ENSDARG00000077012 (1)
GENE EXPRESSION
All Expression Data: text only from Robalino et al., 2004
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12970 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH eif4ea HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Autism, susceptibility to, 19} 615091
    DISEASE ASSOCIATED WITH eif4ea VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process translational initiation (more)
    Cellular Component cytoplasm (more)
    Molecular Function RNA 7-methylguanosine cap binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR019770 Eukaryotic translation initiation factor 4E (eIF-4E), conserved site
    Family IPR001040 Translation Initiation factor eIF- 4e
    Homologous_superfamily IPR023398 Translation Initiation factor eIF- 4e-like
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA eif4ea-201 (1)    Ensembl 1484
    ncRNA eif4ea-002 (1)    Ensembl 590
    eif4ea-003 (1)    Ensembl 730
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM eif4ea No data available
    MARKER RELATIONSHIPS
    eif4ea Contained in: [BAC] CH73-36J8 (1)
    eif4ea Encodes: [cDNA] MGC:86680 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131733 (1) 1464 nt
    Genomic GenBank:CU467639 (1) 118056 nt
    Select Tool
    Polypeptide UniProtKB:F1Q900 (1) 215 aa
    Sequence Information (all 13)
    ORTHOLOGY for eif4ea ( Chr: 14 )
    CITATIONS (24)