Gene
igfbp3
- ID
- ZDB-GENE-040412-1
- Name
- insulin-like growth factor binding protein 3
- Symbol
- igfbp3 Nomenclature History
- Previous Names
-
- IGFBP-3 (1)
- zgc:91788
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Exhibits insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in several processes, including insulin-like growth factor receptor signaling pathway; otic vesicle formation; and pharyngeal system development. Localizes to nucleus. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Is expressed in nervous system; neural crest telencephalon; otic vesicle; pectoral fin; and pharynx. Orthologous to human IGFBP3 (insulin like growth factor binding protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91788 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zhong et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017891 | Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site |
| Domain | IPR000716 | Thyroglobulin type-1 |
| Domain | IPR000867 | Insulin-like growth factor-binding protein, IGFBP |
| Family | IPR012211 | Insulin-like growth factor binding protein 3 |
| Family | IPR022321 | Insulin-like growth factor-binding protein family 1-6, chordata |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR036857 | Thyroglobulin type-1 superfamily |
Domain Details Per Protein
| Protein | Length | Growth factor receptor cysteine-rich domain superfamily | Insulin-like growth factor binding protein 3 | Insulin-like growth factor-binding protein family 1-6, chordata | Insulin-like growth factor-binding protein, IGFBP | Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site | Thyroglobulin type-1 | Thyroglobulin type-1 superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q66I28
|
292 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
igfbp3-201
(1)
|
Ensembl | 806 nt | ||
| mRNA |
igfbp3-202
(1)
|
Ensembl | 3,093 nt |
Interactions and Pathways
No data available
Plasmids
No data available