ZFIN ID: ZDB-GENE-040412-1
Gene Name: insulin-like growth factor binding protein 3
Gene Symbol: igfbp3    Nomenclature History

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Previous Names: IGFBP-3 (1), zgc:91788

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Exhibits insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in several processes, including insulin-like growth factor receptor signaling pathway; otic vesicle formation; and pharyngeal system development. Localizes to nucleus. Is expressed in nervous system; neural crest telencephalon; otic vesicle; pectoral fin; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Orthologous to human IGFBP3 (insulin like growth factor binding protein 3).
Genome Resources: Alliance (1),  Gene:403079 (1),  Ensembl(GRCz11):ENSDARG00000099144 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa23636 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-igfbp3 N/A 2
    MO2-igfbp3 N/A 3
    PHENOTYPE
    Data: Fig. 8 from Zhong et al., 2011
    Observed in:
    DISEASE ASSOCIATED WITH igfbp3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH igfbp3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of BMP signaling pathway (more)
    Cellular Component nucleus (more)
    Molecular Function insulin-like growth factor I binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA igfbp3-201 (1)    Ensembl 806
    igfbp3-202 (1)    Ensembl 3093
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM igfbp3 No data available
    MARKER RELATIONSHIPS
    igfbp3 Contained in: [BAC] CH73-140N19 (1), DKEY-162M2 (1) (order this)
    igfbp3 Encodes: [EST] fq35a06 (1) (order this)
    [cDNA] MGC:91788 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_205751 (1) 3147 nt
    Genomic GenBank:CR926131 (1) 193882 nt
    Select Tool
    Polypeptide UniProtKB:Q66I28 (1) 292 aa
    Sequence Information (all 15)
    ORTHOLOGY for igfbp3 ( Chr: 20 )
    CITATIONS (43)